RT Journal Article
T1 Relationship between symptom impairment and treatment outcome in children and adolescents with attention-deficit/ hyperactivity disorder: a physician perspective
T2 Relación entre el impacto de los síntomas y el resultado del tratamiento en niños y adolescentes con trastorno por déficit de atención/hiperactividad: una perspectiva del médico
A1 Setyawan, Juliana
A1 Fridman, Moshe
A1 Hodgkins, Paul
A1 Quintero Gutiérrez Del Álamo, Francisco Javier
A1 Erder, M Haim
A1 Katić, Božena J.
A1 Harpin, Valerie
AB We evaluated the association between those symptoms/behaviours of attention-deficit/hyperactivity disorder (ADHD) that were present at diagnosis and outcomes of treatment in children and adolescents in six European countries. Physicians abstracted clinical records from patients (6-17 years) diagnosed with ADHD between 2004 and 2007 and treated for ≥2 years. Physicians scored the severity of impairment for core ADHD symptoms and additional (non-core) ADHD symptoms/behaviours at diagnosis and estimated treatment adherence (defined as an estimated >80 % adherence on weekdays and >50 % adherence on weekends). Treatment modalities included pharmacological treatment, behavioural therapy, or both. Pharmacological treatment was further subclassified by medication class. The outcome, optimal treatment success (OTS), was defined as complete symptom control with high satisfaction with treatment. Multivariate logistic regression modelling examined the relationship between OTS and symptom impairment. Of 730 patients, 200 (27 %) achieved OTS. These patients were more likely to demonstrate lower impairment in non-core ADHD symptoms/behaviours and have fewer pre-existing comorbidities. They were also more likely to be adherent and engaged with treatment, with an explicit treatment goal to improve inattention/school performance. Neither core symptoms' severity nor treatment types were associated with OTS. OTS rates were low, with patients having less impairment of non-core ADHD symptoms/behaviours and fewer comorbidities more likely to achieve OTS. Potentially modifiable factors affecting OTS were as follows: treatment adherence, treatment engagement, and a treatment goal to improve inattention/school performance. These data suggest that there may be opportunities to optimize current treatment use, and develop new treatment strategies to improve core and non-core ADHD symptoms/behaviours.
PB Springer
SN 1866-6647
YR 2014
FD 2014-08-23
LK https://hdl.handle.net/20.500.14352/97041
UL https://hdl.handle.net/20.500.14352/97041
LA eng
NO Setyawan J, Fridman M, Hodgkins P, Quintero J, Erder MH, Katić BJ, Harpin V. Relationship between symptom impairment and treatment outcome in children and adolescents with attention-deficit/hyperactivity disorder: a physician perspective. Atten Defic Hyperact Disord. 2015 Mar;7(1):75-87.
NO Shire Development, LLC
DS Docta Complutense
RD 9 abr 2025