%0 Journal Article
%A Benchekroun, Mohamed
%A Romero Hernández, Alejandro
%A Egea, Javier
%A León Martínez, Rafael
%A Michalska Dziama, Patrycja
%A Buendía, Izaskun
%A Jimeno, María Luisa
%A Jun, Daniel
%A Janockova, Jana
%A Sepsova, Vendula
%A Soukup, Ondrej
%A Bautista-Aguilera, Oscar M.
%A Refouvelet, Bernard
%A Ouari, Olivier
%A Marco Contelles, José Luis
%A Ismaili, Lhassane
%T The Antioxidant Additive Approach for Alzheimer’s Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators
%D 2016
%U https://hdl.handle.net/20.500.14352/97148
%X Novel multifunctional tacrines for Alzheimer’s disease were obtained by Ugi-reaction between ferulic (or lipoic acid), a melatonin-like isocyanide, formaldehyde, and tacrine derivatives, according to the antioxidant additive approach in order to modulate the oxidative stress as therapeutic strategy. Compound 5c has been identified as a promising permeable agent showing excellent antioxidant properties, strong cholinesterase inhibitory activity, less hepatotoxicity than tacrine, and the best neuroprotective capacity, being able to significantly activate the Nrf2 transcriptional pathway.
%~