RT Journal Article
T1 The Antioxidant Additive Approach for Alzheimer’s Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators
A1 Benchekroun, Mohamed
A1 Romero Hernández, Alejandro
A1 Egea, Javier
A1 León Martínez, Rafael
A1 Michalska Dziama, Patrycja
A1 Buendía, Izaskun
A1 Jimeno, María Luisa
A1 Jun, Daniel
A1 Janockova, Jana
A1 Sepsova, Vendula
A1 Soukup, Ondrej
A1 Bautista-Aguilera, Oscar
A1 Refouvelet, Bernard
A1 Ouari, Olivier
A1 Marco Contelles, José Luis
A1 Ismaili, Lhassane
AB Novel multifunctional tacrines for Alzheimer’s disease were obtained by Ugi-reaction between ferulic (or lipoic acid), a melatonin-like isocyanide, formaldehyde, and tacrine derivatives, according to the antioxidant additive approach in order to modulate the oxidative stress as therapeutic strategy. Compound 5c has been identified as a promising permeable agent showing excellent antioxidant properties, strong cholinesterase inhibitory activity, less hepatotoxicity than tacrine, and the best neuroprotective capacity, being able to significantly activate the Nrf2 transcriptional pathway.
SN 0022-2623
YR 2016
FD 2016
LK https://hdl.handle.net/20.500.14352/97148
UL https://hdl.handle.net/20.500.14352/97148
LA eng
NO Benchekroun, Mohamed, et al. «The Antioxidant Additive Approach for Alzheimer’s Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators». Journal of Medicinal Chemistry, vol. 59, n.o 21, noviembre de 2016, pp. 9967-73.  https://doi.org/10.1021/acs.jmedchem.6b01178.
NO Conseil régional de Franche-Comté (France)
NO Instituto de Salud Carlos III
NO Faculty of Military Health Sciences, University of Defence (Czech Republic)
NO Bayer AG
NO Fundación FIPSE
NO Ministerio de Educación, Cultura y Deporte (España)
DS Docta Complutense
RD 23 abr 2025