TY  - JOUR
AU  - Benchekroun, Mohamed
AU  - Romero Hernández, Alejandro
AU  - Egea, Javier
AU  - León Martínez, Rafael
AU  - Michalska Dziama, Patrycja
AU  - Buendía, Izaskun
AU  - Jimeno, María Luisa
AU  - Jun, Daniel
AU  - Janockova, Jana
AU  - Sepsova, Vendula
AU  - Soukup, Ondrej
AU  - Bautista-Aguilera, Oscar M.
AU  - Refouvelet, Bernard
AU  - Ouari, Olivier
AU  - Marco Contelles, José Luis
AU  - Ismaili, Lhassane
PY  - 2016
DO  - 10.1021/acs.jmedchem.6b01178
UR  - https://hdl.handle.net/20.500.14352/97148
T2  - Journal of Medicinal Chemistry
AB  - Novel multifunctional tacrines for Alzheimer’s disease were obtained by Ugi-reaction between ferulic (or lipoic acid), a melatonin-like isocyanide, formaldehyde, and tacrine derivatives, according to the antioxidant additive approach in order to...
LA  - eng
M2  - 9967
KW  - Multitarget ligand
KW  - Nrf2 pathway
KW  - Alzheimer´s disease
KW  - Drug discovery
TI  - The Antioxidant Additive Approach for Alzheimer’s Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators
TY  - journal article
VL  - 59
ER  -