RT Journal Article
T1 Bigels as drug delivery systems: From their components to their applications
A1 Martín Illana, Araceli
A1 Notario Pérez, Fernando
A1 Cazorla Luna, Raúl
A1 Ruiz Caro, Roberto
A1 Bonferoni, Maria C.
A1 Tamayo, Aitana
A1 Veiga Ochoa, María Dolores
AB Bigels are systems that usually result from mixing a hydrogel and an organogel: the aqueous phase is commonly formed by a hydrophilic biopolymer, whereas the organic phase comprises a gelled vegetable oil because of the presence of an organogelator. The proportion of the corresponding gelling agent in each phase, the organogel/hydrogel ratio, and the mixing temperature and speed all need to be taken into consideration for bigel manufacturing. Bigels, which are particularly useful drug delivery systems, have already been formulated for transdermal, buccal, and vaginal routes. Mechanical assessments and microscopy are the most reported characterization techniques. As we review here, their composition and unique structure confer promising drug delivery attributes, such as mucoadhesion, the ability to control drug release, and the possibility of including both hydrophilic and lipophilic drugs in the same system.
PB Elsevier
SN 1359-6446
YR 2021
FD 2021-12-20
LK https://hdl.handle.net/20.500.14352/4713
UL https://hdl.handle.net/20.500.14352/4713
LA eng
NO CRUE-CSIC (Acuerdos Transformativos 2021)
NO Ministerio de Ciencia e Innovación (MICINN)/FEDER
DS Docta Complutense
RD 9 abr 2025