RT Journal Article
T1 Serotonin is the main tryptophan metabolite associated with psychiatric comorbidity in abstinent cocaine-addicted patients
A1 Araos, Pedro
A1 Vidal Casado, Rebeca
A1 O'Shea Gaya, María Esther
A1 Rodríguez De Fonseca, Fernando Antonio
A1 Colado Megías, María Isabel
AB The lack of effective treatments and a high rate of relapse in cocaine addiction constitute a major health problem. The present study was conducted to examine the expression of tryptophan-derived metabolites in the context of cocaine addiction and psychiatric comorbidity, which is common in addicted subjects. Abstinent patients with cocaine use disorder (CUD) and control subjects were recruited for a cross-sectional study. Participants were assessed with a semi-structured diagnostic interview (PRISM) based on DSM-IV-TR for substance and mental disorders. Plasma concentrations of tryptophan metabolites and their association with relevant CUD-related variables and psychiatric comorbidity were explored. We observed decreased plasma kynurenic acid concentrations in the cocaine group, however no associations between CUD-related variables and tryptophan-derived metabolites were found. In contrast, 5-HT concentrations were increased in CUD-patients and the diagnosis of different psychiatric disorders in the cocaine group was related to higher plasma 5-HT concentrations compared with non-comorbid patients. Therefore, while changes in plasma kynurenic acid concentrations appear to be directly associated with lifetime CUD, changes in 5-HT concentrations are associated with psychiatric comorbidity. These results emphasize the need to find potential biomarkers for a better stratification of cocaine-addicted patients in order to develop therapeutic approaches to prevent cocaine relapse.
PB Nature
SN 2045-2322
YR 2019
FD 2019-11-14
LK https://hdl.handle.net/20.500.14352/112152
UL https://hdl.handle.net/20.500.14352/112152
LA eng
NO Araos P, Vidal R, O'Shea E, Pedraz M, García-Marchena N, Serrano A, Suárez J, Castilla-Ortega E, Ruiz JJ, Campos-Cloute R, Santín LJ, Rodríguez de Fonseca F, Pavón FJ, Colado MI. Serotonin is the main tryptophan metabolite associated with psychiatric comorbidity in abstinent cocaine-addicted patients. Sci Rep. 2019 Nov 14;9(1):16842. doi: 10.1038/s41598-019-53312-0. PMID: 31727978; PMCID: PMC6856167.
NO Fondos FEDER
NO Instituto de Salud Carlos III (España)
NO Ministerio de Economía y Competitividad (España)
NO Ministerio de Sanidad, Servicios Sociales e Igualdad (España)
NO Junta de Andalucía
NO European Commission
DS Docta Complutense
RD 8 abr 2025