RT Journal Article
T1 Clinical characteristics and risk factors associated with lymphoma in patients with systemic lupus erythematosus: a nationwide cohort study
A1 Martín-López, María
A1 Galindo Izquierdo, María
A1 Martínez Barrio, Julia
A1 Rúa-Figueroa, Iñigo
AB Objectives                  To assess the characteristics and risk of lymphoma in a large cohort of patients with SLE.                                 Methods                  A case–cohort analysis was performed within a dynamic cohort of SLE patients from the Spanish Society of Rheumatology Lupus Registry (RELESSER). Clinical and analytical features were compared between the lymphoma SLE group and the control SLE group using an independent-sample Student’s t-test or Mann–Whitney test for continuous variables and the χ2 test for categorical variables with Fisher’s exact test if necessary. The multivariate analysis was based on a generalized linear model.                                 Results                  Twenty-one patients with SLE and lymphoma and 3965 non-lymphoma controls with SLE were studied. Most lymphomas were of B cell origin (n = 15/21), with diffuse large B cell lymphoma being the most frequent histological type (8/21, 38.1%). As in the general population, the risk of lymphoma in SLE was higher in male than in female patients and increased with age. In the lymphoma SLE group, bivariate analysis showed a significantly higher percentage of pericarditis, organic brain syndrome, seizures, vasculitis, haemolytic anaemia, splenomegaly, venous thrombosis and mean modified (excluding lymphoma) SLICC/ACR damage index. In contrast, renal involvement, positive anti-dsDNA, and antimalarials ever were less frequent.                                 Conclusions                  In this large multicentre Spanish cohort, we identified characteristics of SLE that are associated with a higher risk of lymphoma. Antimalarials were significantly negatively associated with risk of lymphoma in SLE patients. Nevertheless, further prospective studies are needed to clarify these findings.
PB Oxford University Press
SN 1462-0324
SN 1462-0332
YR 2022
FD 2022-04-28
LK https://hdl.handle.net/20.500.14352/114240
UL https://hdl.handle.net/20.500.14352/114240
LA eng
NO Martín-López M, Galindo M, Pego-Reigosa JM, Jiménez N, Olivé Marqués A, Tomero E, Freire M, Martínez-Barrio J, Boteanu A, Salgado-Perez E, Fernández-Nebro A, Calvo J, Menor-Almagro R, Rúa-Figueroa I. Clinical characteristics and risk factors associated with lymphoma in patients with systemic lupus erythematosus: a nationwide cohort study. Rheumatology (Oxford). 2022 Dec 23;62(1):217-224.
DS Docta Complutense
RD 8 abr 2025