RT Journal Article
T1 Collagen IV and laminin-1 as key macromolecules in ocular structure and pathology: A review
A1 Sijilmassi, Ouafa
AB The extracellular matrix (ECM), particularly the basement membrane (BM), is critical for the structural organization and functionality of ocular tissues. Among its core components, type IV collagen and laminin-1 play central roles in cell adhesion, polarity, differentiation, and survival. These macromolecules are ubiquitously expressed in the cornea, lens, retina, and optic nerve, forming tissue-specific BMs that support development and homeostasis. In this review, findings on the spatial distribution and molecular roles of collagen IV and laminin-1 in the eye under physiological and pathological conditions, are summarized. Mutations in COL4A1, COL4A2, and laminin-encoding genes (LAMA1, LAMB1, LAMC1) are associated with a range of ocular disorders, including anterior segment dysgenesis, lens dystrophy, optic nerve hypoplasia, and retinal abnormalities. Furthermore, autoimmune responses targeting these BM proteins have been implicated in systemic diseases such as rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, and Sjögren's syndrome, often leading to serious ocular complications. This review emphasizes the importance of ECM macromolecules in maintaining ocular integrity and highlights their potential as diagnostic biomarkers and therapeutic targets in both inherited and immune-mediated eye diseases.
PB Elsevier
YR 2025
FD 2025-12
LK https://hdl.handle.net/20.500.14352/133683
UL https://hdl.handle.net/20.500.14352/133683
LA eng
NO Sijilmassi, Ouafa. «Collagen IV and Laminin-1 as Key Macromolecules in Ocular Structure and Pathology: A Review». International Journal of Biological Macromolecules, vol. 334, diciembre de 2025, p. 149013. DOI.org (Crossref), https://doi.org/10.1016/j.ijbiomac.2025.149013
DS Docta Complutense
RD 12 mar 2026