RT Journal Article
T1 Effects of Gluten on Gut Microbiota in Patients with Gastrointestinal Disorders, Migraine, and Dermatitis
A1 San Mauro Martín, Ismael
A1 López Oliva, Sara
A1 Garicano Vilar, Elena
A1 Sánchez Niño, Guerthy Melissa
A1 Penadés, Bruno F
A1 Terrén Lora, Ana
A1 Sanz Rojo, Sara
A1 Collado Yurrita, Luis Rodolfo
AB As gluten may trigger gastrointestinal disorders (GIDs), its presence or absence in the diet can change the diversity and proportion of gut microbiota. The effects of gluten after six weeks of a double-blind, placebo-controlled intervention with a gluten-free diet (GFD) were studied in participants with GIDs suffering from migraines and atopic dermatitis (n = 46). Clinical biomarkers, digestive symptoms, stool, the Migraine Disability Assessment questionnaire, and zonulin levels were analyzed. Next-generation sequencing was used to amplify the 16S rRNA gene of bacteria and the internal transcribed spacer (ITS) regions of fungi. The GFD increased Chao1 fungal diversity after the intervention, while the fungal composition showed no changes. Bacterial diversity and composition remained stable, but a positive association between bacterial and fungal Chao1 diversity and a negative association between Dothideomycetes and Akkermansia were observed. GIDs decreased in both groups and migraines improved in the placebo group. Our findings may aid the development of GID treatment strategies.
PB MDPI
YR 2024
FD 2024-04-20
LK https://hdl.handle.net/20.500.14352/128704
UL https://hdl.handle.net/20.500.14352/128704
LA eng
NO San Mauro Martín I, López Oliva S, Garicano Vilar E, Sánchez Niño GM, Penadés BF, Terrén Lora A, Sanz Rojo S, Collado Yurrita L. Effects of Gluten on Gut Microbiota in Patients with Gastrointestinal Disorders, Migraine, and Dermatitis. Nutrients. 2024 Apr 20;16(8):1228. doi: 10.3390/nu16081228. PMID: 38674918; PMCID: PMC11053402.
DS Docta Complutense
RD 19 mar 2026