%0 Journal Article
%A Wang, Hanfei
%A Wang, Boyu
%A Zhang, Jieying
%A Tong, Haibin
%A Ares Lombán, Irma
%A Martínez Caballero, Marta
%A López Torres, Bernardo
%A Martínez Larrañaga, María Rosa
%A Pan, Yuanhu
%A Zhang, Jinjun
%A Anadón Navarro, Arturo Ramón
%A Wang, Xu
%A Martínez Caballero, María Aranzazu
%T Concurrent management of gout and type 2 diabetes mellitus: combined therapy insights
%D 2026
%@ 0168-8227
%U https://hdl.handle.net/20.500.14352/134112
%X Gout and type 2 diabetes mellitus (T2DM) are prevalent metabolic disorders with a significant bidirectional association. The review article focuses on the interplay between serum uric acid and glucose/lipid metabolism, innate immunity, inflammation, and gut microbiota, proposing simultaneous treatment strategies. Gout, caused by monosodium urate crystal deposition due to hyperuricaemia, and T2DM, induced by high-fat, high-sugar diets disrupting metabolic balance, share common pathological mechanisms. Elevated uric acid levels contribute to lipid and glucose metabolic disorders, activate inflammatory pathways like the nucleotide-binding oligomerization domain-like receptor 3 inflammasome, and trigger innate immune responses. The gut microbiota also plays a significant role in both metabolic diseases, with dysbiosis affecting uric acid excretion and insulin resistance. This review article highlights promising therapeutic approaches, including the use of sodium-glucose cotransporter-2 inhibitors which reduce serum uric acid and lowers gout risk alongside glycaemic control. Additionally, targeting inflammatory pathways such as interleukin-1β offers potential benefits for both conditions. Combined pharmacological therapies, dietary adjustments, and gut microbiota interventions present new directions for simultaneous management. This review article provides a comprehensive analysis of the links between gout and T2DM, offering novel insights for clinical practice and future research
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