RT Journal Article
T1 Concurrent management of gout and type 2 diabetes mellitus: combined therapy insights
A1 Wang, Hanfei
A1 Wang, Boyu
A1 Zhang, Jieying
A1 Tong, Haibin
A1 Ares Lombán, Irma
A1 Martínez Caballero, Marta
A1 López Torres, Bernardo
A1 Martínez Larrañaga, María Rosa
A1 Pan, Yuanhu
A1 Zhang, Jinjun
A1 Anadón Navarro, Arturo Ramón
A1 Wang, Xu
A1 Martínez Caballero, María Aranzazu
AB Gout and type 2 diabetes mellitus (T2DM) are prevalent metabolic disorders with a significant bidirectional association. The review article focuses on the interplay between serum uric acid and glucose/lipid metabolism, innate immunity, inflammation, and gut microbiota, proposing simultaneous treatment strategies. Gout, caused by monosodium urate crystal deposition due to hyperuricaemia, and T2DM, induced by high-fat, high-sugar diets disrupting metabolic balance, share common pathological mechanisms. Elevated uric acid levels contribute to lipid and glucose metabolic disorders, activate inflammatory pathways like the nucleotide-binding oligomerization domain-like receptor 3 inflammasome, and trigger innate immune responses. The gut microbiota also plays a significant role in both metabolic diseases, with dysbiosis affecting uric acid excretion and insulin resistance. This review article highlights promising therapeutic approaches, including the use of sodium-glucose cotransporter-2 inhibitors which reduce serum uric acid and lowers gout risk alongside glycaemic control. Additionally, targeting inflammatory pathways such as interleukin-1β offers potential benefits for both conditions. Combined pharmacological therapies, dietary adjustments, and gut microbiota interventions present new directions for simultaneous management. This review article provides a comprehensive analysis of the links between gout and T2DM, offering novel insights for clinical practice and future research
PB Elsevier
SN 0168-8227
YR 2026
FD 2026
LK https://hdl.handle.net/20.500.14352/134112
UL https://hdl.handle.net/20.500.14352/134112
LA eng
NO Wang, H., Wang, B., Zhang, J., Tong, H., Ares, I., Martínez, M., Lopez-Torres, B., Martínez-Larrañaga, M. R., Pan, Y., Zhang, J., Anadón, A., Wang, X., & Martínez, M. A. (2026). Concurrent management of gout and type 2 diabetes mellitus: combined therapy insights. Diabetes research and clinical practice, 234, 113169. https://doi.org/10.1016/j.diabres.2026.113169
NO Credit authorship contribution statementHanfei Wang: Writing – review & editing, Writing – original draft, Visualization, Conceptualization. Boyu Wang: Writing – review & editing, Writing – original draft, Visualization, Conceptualization. Jieying Zhang: Writing – review & editing, Writing – original draft, Visualization, Conceptualization. Haibin Tong: Writing – review & editing, Writing – original draft, Visualization, Conceptualization. Irma Ares: Writing – review & editing, Investigation, Formal analysis, Data curation, Conceptualization. Marta Martínez: Writing – review & editing, Investigation, Formal analysis, Data curation, Conceptualization. Bernardo Lopez-Torres: Writing – review & editing, Investigation, Formal analysis, Data curation, Conceptualization. María-Rosa Martínez-Larrañaga: Writing – review & editing, Investigation, Formal analysis, Data curation, Conceptualization. Yuanhu Pan: Writing – review & editing, Writing – original draft, Visualization, Conceptualization. Jinjun Zhang: Writing – review & editing, Writing – original draft, Visualization, Conceptualization. Arturo Anadón: Writing – review & editing, Supervision, Resources, Project administration. Xu Wang: Writing – review & editing, Supervision, Resources, Project administration. María-Aránzazu Martínez: Writing – review & editing, Supervision, Resources, Project administration
NO National Key R&D Program of China
NO Ministerio de Ciencia, innovación y Universidades (España)
NO Univerzita Hradec Králové
DS Docta Complutense
RD 10 abr 2026