TY - JOUR AU - Alén, Rosa AU - García-Martínez, Irma AU - Cobo-Vuilleumier, Nadia AU - Fernández Millán, Elisa AU - Gallardo-Villanueva, Paula AU - Ferreira, Vitor AU - Izquierdo, Manuel AU - Moro, María Ángeles AU - Lizasoaín Hernández, Ignacio AU - Nieto, Natalia AU - Gauthier, Benoit R. AU - Valverde, A.M. PY - 2025 DO - 10.1007/s00125-025-06445-z UR - https://hdl.handle.net/20.500.14352/126078 T2 - Diabetologia AB - Aims/hypothesis: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common feature of obesity and type 2 diabetes. Under lipotoxic stress, hepatocytes release small extracellular vesicles (sEVs) which act locally and contribute to... LA - eng PB - Springer KW - Beta cells KW - Extracellular vesicles KW - Islet macrophages KW - Metabolic dysfunction-associated steatotic liver disease KW - Toll-like receptor 4 KW - Type 2 diabetes TI - Effect of lipotoxic hepatocyte‑derived extracellular vesicles in pancreas inflammation: essential role of macrophage TLR4 in beta cell functionality. TY - journal article ER -