RT Journal Article
T1 Temperament in child and adolescent offspring of patients with schizophrenia and bipolar disorder
A1 Díaz Caneja, Covadonga M.
A1 Morón Nozaleda, María Goretti
A1 Vicente Moreno, Raquel P.
A1 Rodríguez Toscano, Elisa
A1 Pina Camacho, Laura
A1 De la Serna, Elena
A1 Sugranyes, Gisela
A1 Baeza, Inmaculada
A1 Romero, Soledad
A1 Sanchez Gistau, Vanessa
A1 Castro Fornieles, Josefina
A1 Moreno Ruiz, María del Carmen
A1 Moreno Pardillo, Dolores María
AB Shared vulnerability in offspring of individuals with schizophrenia (SzO) and bipolar disorder (BpO) might manifest early during development through common temperament traits. Temperament dimensions in child and adolescent BpO (N = 80), SzO (N = 34) and the offspring of community controls (CcO) (N = 101) were assessed using the Revised Dimensions of Temperament Survey. The association between temperament dimensions and lifetime psychopathology (including threshold and subthreshold DSM-IV-TR diagnoses) and current socio-academic adjustment was assessed using logistic regression. Fully adjusted models showed that both BpO and SzO scored significantly lower in the positive mood dimension and in the adaptability factor than CcO, with small–medium effect sizes (Cohen’s d ~ 0.3–0.5). BpO also scored lower in the activityfactor and the activity dimensions than CcO (Cohen’s d ~ 0.3). Lower scores in the positive mood dimension were associated with increased risk of impaired adjustment both in BpO [OR 2.30, 95% CI (1.18–4.46)] and in SzO [OR 2.87, 95% CI (1.07–7.66)]. In BpO, lower scores in positive mood were also associated with  increased likelihood of internalizing [OR 1.84, 95% CI (1.28–2.64)] and externalizing disorders [OR 1.48, 95% CI (1.01–2.18)]; in SzO, higher scores in activity and flexibility were associated with increased likelihood of internalizing [OR 2.31, 95% CI (1.22–4.38)] and externalizing disorders [OR 3.28, 95% CI (1.2–9)], respectively. Early difficulties in emotion regulation might represent a shared vulnerabilityphenotype in BpO and SzO. The identification of extreme temperament traits could help to characterize subgroups at greater risk of psychopathology and impaired adjustment, in which targeted interventions are warranted.
PB Springer
SN 1018-8827
SN 1435-165X
YR 2018
FD 2018-03-08
LK https://hdl.handle.net/20.500.14352/114213
UL https://hdl.handle.net/20.500.14352/114213
LA eng
NO Díaz Caneja, C. M., Morón Nozaleda, M. G., Vicente Moreno, R. P., Rodríguez Toscano, E., Pina Camacho, L., De La Serna, E., Sugranyes, G., Baeza, I., Romero, S., Sánchez Gistau, V., Castro Fornieles, J., Moreno, C., & Moreno, D. (2018). Temperament in child and adolescent offspring of patients with schizophrenia and bipolar disorder. European Child & Adolescent Psychiatry, 27(11), 1459-1471. https://doi.org/10.1007/s00787-018-1135-Y
DS Docta Complutense
RD 8 abr 2025