RT Journal Article
T1 Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles.
A1 Gisbert Garzarán, Miguel
A1 Vallet Regí, María Dulce Nombre
AB Mesoporous silica nanoparticles have been broadly applied as drug delivery systems 14 owing to their exquisite features, such as excellent textural properties or biocompatibility. However, 15 there are various biological barriers that prevent their proper translation into the clinic, including 16 (1) lack of selectivity toward tumor tissues, (2) lack of selectivity for tumoral cells and (3) endosomal 17 sequestration of the particles upon internalization. In addition, their open porous structure may 18 lead to premature drug release, consequently affecting healthy tissues and decreasing the efficacy 19 of the treatment. First, this review will provide a comprehensive and systematic overview of the 20 different approximations that have been implemented into mesoporous silica nanoparticles to 21 overcome each of such biological barriers. Afterward, the potential premature and non-specific drug 22 release from these mesoporous nanocarriers will be addressed by introducing the concept of stimuli23 responsive gatekeepers, which endow the particles with on-demand and localized drug delivery.
PB MDPI
SN 2079-4991
YR 2020
FD 2020-05-09
LK https://hdl.handle.net/20.500.14352/6236
UL https://hdl.handle.net/20.500.14352/6236
LA eng
NO RESEARCHER ID S-2443-2016 (Miguel Gisbert Garzarán)ORCID 0000-0001-9815-0354 (Miguel Gisbert Garzarán)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea. Horizonte 2020
DS Docta Complutense
RD 11 abr 2025