RT Journal Article
T1 The status of the lysophosphatidic acid receptortype 1 (LPA1R)
A1 González Gil, Inés
A1 Zian, Debora
A1 Vázquez Villa, María Del Henar
A1 Ortega Gutiérrez, Silvia
A1 López Rodríguez, María Luz
AB Lysophospholipids are lipid molecules that are receiving growing attention because, in addition to their structural function in the cell membrane, they are now regarded as important regulators for diverse biological functions through activation of specific receptors. These receptors have been characterized during the last two decades as G protein-coupled receptors (GPCRs) and, among them, two families stand out: lysophosphatidic acid (LPA1–6) and sphingosine 1-phoshate (S1P1–5) receptors. Despite their interest, the high structural similarity between them has restrained the development of selective and high affinity ligands and therefore the elucidation of the role of these receptors in the central nervous system (CNS). This review provides an overview about the different LPA receptors with a special focus on the LPA1 subtype from a medicinal chemistry perspective. It summarizes the most recent developments in the search for selective and specific agonists and antagonists of the LPA1 receptor and highlights their current status in the drug development pipeline.
PB Royal Society of Chemistry (UK)
SN 2040-2503 (Print) , 2040-2511 (Online)
YR 2015
FD 2015
LK https://hdl.handle.net/20.500.14352/34958
UL https://hdl.handle.net/20.500.14352/34958
LA eng
NO Ministerio ee Eeconomía y Competitividad (MINECO)
NO Comunidad de Madrid
DS Docta Complutense
RD 20 ene 2026