RT Journal Article
T1 Mechanics of Constriction during Cell Division: A Variational Approach
T2 Mecánica de la constricción durante la división celular: un enfoque variacional
A1 Almendro Vedia, Víctor Galileo
A1 Monroy Muñoz, Francisco
A1 Cao García, Francisco Javier
A2 Soldati, Thierry
AB During symmetric division cells undergo large constriction deformations at a stable midcell site. Using a variational approach, we investigate the mechanical route for symmetric constriction by computing the bending energy of deformed vesicles with rotational symmetry. Forces required for constriction are explicitly computed at constant area and constant volume, and their values are found to be determined by cell size and bending modulus. For cell-sized vesicles, considering typical bending modulus of k = 10kBT, we calculate constriction forces in the range 0.1 - 1pN. The instability of symmetrical constriction is shown and quantified with a characteristic coefficient of the order of - 50kBT, thus evidencing that cells need a robust mechanism to stabilize constriction at midcell.
PB Public Library Science
SN 1932-6203
YR 2013
FD 2013-08-21
LK https://hdl.handle.net/20.500.14352/92152
UL https://hdl.handle.net/20.500.14352/92152
LA eng
NO Almendro-Vedia, V.G., Monroy, F., Cao, F.J.: Mechanics of Constriction during Cell Division: A Variational Approach. PLOS ONE. 8, e69750 (2013). https://doi.org/10.1371/journal.pone.0069750
NO Funding: This work was supported by Ministerio de Ciencia e Innovación and Ministerio de Economı´a y Competitividad (Spain) under grants FIS 2010-17440 to FJC and FIS2009-14650- C02-01, FIS2012-35723, Consolider Ingenio en Nanociencia Molecular CSD2007-0010, and S2009MAT-1507 from Comunidad Autonoma de Madrid (Spain) to FM. VGAV acknowledges support from Ministerio de Educacio´n Cultura y Deporte (Spain) through Becas de Colaboracio´n program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Ministerio de Economía, Comercio y Empresa (España)
NO Comunidad de Madrid
NO Ministerio de Educación, Formación Profesional y Deportes (España)
DS Docta Complutense
RD 17 abr 2025