RT Journal Article
T1 The Global Deterioration Scale for Down Syndrome Population (GDS-DS): A Rating Scale to Assess the Progression of Alzheimer’s Disease
A1 Rodríguez-Hidalgo, Emili
A1 Novell, Ramon
A1 Esteba-Castillo, Susanna
A1 García Alba, Javier
AB The aim of this study is to adapt and validate the global deterioration scale (GDS) for the systematic tracking of Alzheimer’s disease (AD) progression in a population with Down syndrome (DS). A retrospective dual-center cohort study was conducted with 83 participants with DS (46.65 ± 5.08 years) who formed the primary diagnosis (PD) group: cognitive stability (n = 48), mild cognitive impairment (n = 24), and Alzheimer’s disease (n = 11). The proposed scale for adults with DS (GDS-DS) comprises six stages, from cognitive and/or behavioral stability to advanced AD. Two neuropsychologists placed the participants of the PD group in each stage of the GDS-DS according to cognitive, behavioral and daily living skills data. Inter-rater reliability in staging with the GDS-DS was excellent (ICC = 0.86; CI: 0.80–0.93), and the agreement with the diagnosis categories of the PD group ranged from substantial to excellent with κ values of 0.82 (95% CI: 0.73–0.92) and 0.85 (95% CI: 0.72, 0.99). Performance with regard to the CAMCOG-DS total score and orientation subtest of the Barcelona test for intellectual disability showed a slight progressive decline across all the GDS-DS stages. The GDS-DS scale is a sensitive tool for staging the progression of AD in the DS population, with special relevance in daily clinical practice.
PB MPDI
YR 2023
FD 2023-03-14
LK https://hdl.handle.net/20.500.14352/103647
UL https://hdl.handle.net/20.500.14352/103647
LA eng
NO Rodríguez-Hidalgo, E.; García-Alba, J.; Novell, R.; Esteba-Castillo, S. The Global Deterioration Scale for Down Syndrome Population (GDS-DS): A Rating Scale to Assess the Progression of Alzheimer’s Disease. Int. J. Environ. Res. Public Health 2023, 20, 5096. https://doi.org/10.3390/ijerph20065096
NO Gobierno de España
NO Servicio Especializado en Salud Mental para Personas con discapacidad intelectual
DS Docta Complutense
RD 6 abr 2025