RT Journal Article
T1 Olive Leaf Extract Supplementation to Old Wistar Rats Attenuates Aging-Induced Sarcopenia and Increases Insulin Sensitivity in Adipose Tissue and Skeletal Muscle
A1 González Hedström, Daniel
A1 Priego Cuadra, Teresa
A1 Amor, Sara
A1 Fuente Fernández, María de la
A1 Martín Velasco, Ana Isabel
A1 López-Calderón Barreda, Asunción
A1 Inarejos García, Antonio Manuel
A1 García Villalón, Ángel Luís
A1 Granado, Miriam
AB Aging is associated with increased visceral adiposity and a decrease in the amount of brown adipose tissue and muscle mass, known as sarcopenia, which results in the development of metabolic alterations such as insulin resistance. In this study, we aimed to analyze whether 3-week supplementation with a phenolic-rich olive leaf extract (OLE) to 24 months-old male Wistar rats orally (100 mg/kg) attenuated the aging-induced alterations in body composition and insulin resistance. OLE treatment increased brown adipose tissue and attenuated the aging-induced decrease in protein content and gastrocnemius weight. Treatment with OLE prevented the aging-induced increase in the expression of PPAR-γ in visceral and brown adipose tissues, while it significantly increased the expression of PPAR-α in the gastrocnemius of old rats and reduced various markers related to sarcopenia such as myostatin, HDAC-4, myogenin and MyoD. OLE supplementation increased insulin sensitivity in explants of gastrocnemius and epididymal visceral adipose tissue from aged rats through a greater activation of the PI3K/Akt pathway, probably through the attenuation of inflammation in both tissues. In conclusion, supplementation with OLE prevents the loss of muscle mass associated with aging and exerts anti-inflammatory and insulin-sensitizing effects on adipose tissue and skeletal muscle.
PB MPDI
SN 2076-3921
YR 2021
FD 2021-05-07
LK https://hdl.handle.net/20.500.14352/7129
UL https://hdl.handle.net/20.500.14352/7129
LA eng
NO Comunidad de Madrid
DS Docta Complutense
RD 12 abr 2025