RT Journal Article
T1 Antimycobacterial effect of selenium nanoparticles on Mycobacterium tuberculosis.
A1 Estévez Sánchez, Héctor
A1 Palacios, Ainhoa
A1 Gil, David
A1 Anguita, Juan
A1 Vallet Regí, María Dulce Nombre
A1 González Ortiz, Blanca
A1 Prados Rosales, Rafael
A1 Luque-García, José L.
AB Tuberculosis remains the leading cause of death from a single infection agent worldwide. In recent years, the occurrence of tuberculosis cases caused by drug-resistant strains has spread, and is expected to continue to grow. Therefore, the development of new alternative treatments to the use of antibiotics is highly important. In that sense, nanotechnology can play a very relevant role, due to the unique characteristics of nanoparticles. In fact, different types of nanoparticles have already been evaluated both as potential bactericides and as efficient drug delivery vehicles. In this work, the use of selenium nanoparticles has been evaluated to inhibit the growth of two types of mycobacteria: Mycobacterium smegmatis and Mycobacterium tuberculosis. The results showed that selenium nanoparticles are able to inhibit the growth of both types of mycobacteria by damaging their cell envelope integrity. These results open a new opportunity for the use of this type of nanoparticles as antimycobacterial agents by themselves, or for the development of novel nanosystems that combine the action of these nanoparticles with other drugs.
PB Frontiers Media SA
SN 1664-302X
YR 2020
FD 2020-04-28
LK https://hdl.handle.net/20.500.14352/6209
UL https://hdl.handle.net/20.500.14352/6209
LA eng
NO RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)RESEARCHER ID K-4773-2015 (Blanca González Ortiz)ORCID 0000-0002-0493-6071 (Blanca González Ortiz)
NO Unión Europea. Horizonte 2020
NO Ministerio de Economía y Competitividad (MINECO)
NO Centro de Excelencia Severo Ochoa
NO Ministerio de Ciencia e Innovación (MICINN)
NO Gobierno Vasco
DS Docta Complutense
RD 22 jul 2024