RT Journal Article
T1 Infectious Complications Following Small Bowel Transplantation
A1 Silva, J. T.
A1 San Juan, R.
A1 Fernández Caamaño, B.
A1 Prieto Bozano, G.
A1 Fernández Ruiz, M.
A1 Lumbreras, C.
A1 Calvo Pulido, Jorge
A1 Jiménez Romero, Luis Carlos
A1 Resino Foz, E.
A1 López Medrano, Francisco
A1 López Santamaria, M.
A1 Aguado, J. María
AB Microbiological spectrum and outcome of infectious complications following small bowel transplantation (SBT) have not been thoroughly characterized. We performed a retrospective analysis of all patients undergoing SBT from 2004 to 2013 in Spain. Sixty-nine patients underwent a total of 87 SBT procedures (65 pediatric, 22 adult). The median follow-up was 867 days. Overall, 81 transplant patients (93.1%) developed 263 episodes of infection (incidence rate: 2.81 episodes per 1000 transplant-days), with no significant differences between adult and pediatric populations. Most infections were bacterial (47.5%). Despite universal prophylaxis, 22 transplant patients (25.3%) developed cytomegalovirus disease, mainly in the form of enteritis. Specifically, 54 episodes of opportunistic infection (OI) occurred in 35 transplant patients. Infection was the major cause of mortality (17 of 24 deaths). Multivariate analysis identified retransplantation (hazard ratio [HR]: 2.21; 95% confidence interval [CI]: 1.02–4.80; p = 0.046) and posttransplant renal replacement therapy (RRT; HR: 4.19; 95% CI: 1.40–12.60; p = 0.011) as risk factors for OI. RRT was also a risk factor for invasive fungal disease (IFD; HR: 24.90; 95% CI: 5.35–115.91; p < 0.001). In conclusion, infection is the most frequent complication and the leading cause of death following SBT. Posttransplant RRT and retransplantation identify those recipients at high risk for developing OI and IFD.
PB Wiley
SN 1600-6135
YR 2015
FD 2015-09-09
LK https://hdl.handle.net/20.500.14352/115335
UL https://hdl.handle.net/20.500.14352/115335
LA eng
NO Silva JT, San-Juan R, Fernández-Caamaño B, Prieto-Bozano G, Fernández-Ruiz M, Lumbreras C, Calvo-Pulido J, Jiménez-Romero C, Resino-Foz E, López-Medrano F, Lopez-Santamaria M, Maria Aguado J. Infectious Complications Following Small Bowel Transplantation. Am J Transplant. 2016 Mar;16(3):951-9. doi: 10.1111/ajt.13535. Epub 2015 Nov 11. PMID: 26560685.
NO Instituto de Salud Carlos III
NO Ministerio de Economía y Competitividad (España)
NO Unión Europea
DS Docta Complutense
RD 9 abr 2025