RT Journal Article
T1 Immunomodulatory role of microRNAs transferred by extracellular vesicles
A1 Fernández Messina, Lola María
A1 Gutiérrez‐Vázquez, Cristina
A1 Rivas‐García, Eva
A1 Sánchez‐Madrid, Francisco
A1 Fuente, Hortensia de la
AB The immune system is composed of different cell types localised throughout the organism to sense and respond to pathological situations while maintaining homeostasis under physiological conditions. Intercellular communication between immune cells is essential to coordinate an effective immune response and involves both cell contact dependent and independent processes that ensure the transfer of information between bystander and distant cells. There is a rapidly growing body of evidence on the pivotal role of extracellular vesicles (EVs) in cell communication and these structures are emerging as important mediators for immune modulation upon delivery of their molecular cargo. In the last decade, EVs have been shown to be efficient carriers of genetic information, including microRNAs (miRNAs), that can be transferred between cells and regulate gene expression and function on the recipient cell. Here, we review the current knowledge of intercellular functional transfer of EV‐delivered miRNAs and their putative role in immune regulation.
PB Wiley
SN 0248-4900
YR 2015
FD 2015
LK https://hdl.handle.net/20.500.14352/97163
UL https://hdl.handle.net/20.500.14352/97163
LA eng
NO Fernández‐Messina, Lola, et al. «Immunomodulatory Role of microRNAs Transferred by Extracellular Vesicles». Biology of the Cell, vol. 107, n.o 3, marzo de 2015, pp. 61-77. https://doi.org/10.1111/boc.201400081.
NO FundingThis work is supported by grants SAF2011-25834, ERC-2011-ADG_20110310, Cardiovascular Network RD12-0042-0056 (Instituto de Salud Carlos III), PIE-13-00041 and INDISNET S2011-BMD-2332. L.F.M. is supported by the Juan de la Cierva grant (Spanish Ministry of Economy and Competitivity) and E.R.G. by the Spanish Ministry of Health.
NO Instituto de Salud Carlos III
NO Ministerio de Economía y Competitividad (España)
NO Ministerio de Sanidad (España)
DS Docta Complutense
RD 26 feb 2026