RT Journal Article
T1 Contribution of Autophagy to Epithelial Mesenchymal Transition Induction during Cancer Progression
A1 Strippoli, Raffaele
A1 Niayesh-Mehr, 
A1 Adelipour, Maryam
A1 Khosravi, Arezoo
A1 Cordani, Marco
A1 Zarrabi, Ali
A1 Allameh, Abdolamir
AB Epithelial Mesenchymal Transition (EMT) is a dedifferentiation process implicated in many physio-pathological conditions including tumor transformation. EMT is regulated by several extracellular mediators and under certain conditions it can be reversible. Autophagy is a conserved catabolic process in which intracellular components such as protein/DNA aggregates and abnormal organelles are degraded in specific lysosomes. In cancer, autophagy plays a controversial role, acting in different conditions as both a tumor suppressor and a tumor-promoting mechanism. Experimental evidence shows that deep interrelations exist between EMT and autophagy-related pathways. Although this interplay has already been analyzed in previous studies, understanding mechanisms and the translational implications of autophagy/EMT need further study. The role of autophagy in EMT is not limited to morphological changes, but activation of autophagy could be important to DNA repair/damage system, cell adhesion molecules, and cell proliferation and differentiation processes. Based on this, both autophagy and EMT and related pathways are now considered as targets for cancer therapy. In this review article, the contribution of autophagy to EMT and progression of cancer is discussed. This article also describes the multiple connections between EMT and autophagy and their implication in cancer treatment.
PB MDPI
YR 2024
FD 2024-02-16
LK https://hdl.handle.net/20.500.14352/101560
UL https://hdl.handle.net/20.500.14352/101560
LA eng
NO Strippoli, R.; Niayesh-Mehr, R.; Adelipour, M.; Khosravi, A.; Cordani, M.; Zarrabi, A.; Allameh, A. Contribution of Autophagy to Epithelial Mesenchymal Transition Induction during Cancer Progression. Cancers 2024, 16, 807. https://doi.org/10.3390/cancers16040807
NO Ministerio de Ciencia e Innovación (España)
NO European Commission
NO Ministry of Health and Medical Education (UK)
NO Ministry of University and Research (Italy)
DS Docta Complutense
RD 17 abr 2025