RT Journal Article
T1 Organelle-specific initiation of cell death
A1 Galluzzi, Lorenzo
A1 Bravo San Pedro, José Manuel
A1 Kroemer, Guido
AB In a majority of pathophysiological settings, cell death is not accidental - it is controlled by a complex molecular apparatus. Such a system operates like a computer: it receives several inputs that inform on the current state of the cell and the extracellular microenvironment, integrates them and generates an output. Thus, depending on a network of signals generated at specific subcellular sites, cells can respond to stress by attempting to recover homeostasis or by activating molecular cascades that lead to cell death by apoptosis or necrosis. Here, we discuss the mechanisms whereby cellular compartments - including the nucleus, mitochondria, plasma membrane, endoplasmic reticulum, Golgi apparatus, lysosomes, cytoskeleton and cytosol - sense homeostatic perturbations and translate them into a cell-death-initiating signal.
PB Springer Nature
SN 1476-4679
YR 2014
FD 2014-08-01
LK https://hdl.handle.net/20.500.14352/129094
UL https://hdl.handle.net/20.500.14352/129094
LA eng
NO Galluzzi L, Bravo-San Pedro JM, Kroemer G. Organelle-specific initiation of cell death. Nat Cell Biol. 2014 Aug;16(8):728–736.
DS Docta Complutense
RD 21 mar 2026