TY - JOUR AU - Rapún, Josu AU - Pérez Martín, Sara AU - Cámara Checa, Anabel AU - San José, Gorka AU - Núñez Fernández, Roberto AU - Crespo García, María Teresa AU - Hoban, Adam AU - Rubio Alarcón, Marcos AU - Martínez Blanco, Elena AU - Tamargo Menéndez, Juan AU - Díez Guerra, F. Javier AU - López, Begoña AU - Gómez García, Ricardo AU - González, Arantxa AU - Delpón Mosquera, María Eva AU - Caballero Collado, Ricardo PY - 2025 DO - 10.1016/j.biopha.2025.117984 UR - https://hdl.handle.net/20.500.14352/119732 T2 - Biomedicine & Pharmacotherapy AB - AbstractDapagliflozin and empagliflozin exert many cardiovascular protective actions in heart failure (HF) patients. HF-induced electrical remodelling decreases the expression of Nav1.5 channels (encoded by SCN5A) that generate the cardiac Na+ current... LA - eng M2 - 117984 PB - Elsevier KW - Dapagliflozin KW - Empagliflozin KW - Na+ current KW - Patch-clamp KW - Cardiac TI - Two concurrent mechanisms are responsible for the INa increase produced by dapagliflozin and empagliflozin in healthy and heart failure cardiomyocytes TY - journal article VL - 186 ER -