RT Journal Article
T1 Antioxidant and Hepatoprotective Effects of Croton hypoleucus Extract in an Induced-Necrosis Model in Rats
A1 Urrutia Hernández, Thania Alejandra
A1 Santos López, Jorge Arturo
A1 Benedí González, Juana María
A1 Sánchez Muniz, Francisco José
A1 Velázquez González, Claudia
A1 De la O-Arciniega, Minarda
A1 Jaramillo Morales, Osmar Antonio
A1 Bautista, Mirandeli
AB The aim of this study was to evaluate the antioxidant and hepatoprotective activity of Croton hypoleucus (EC). The present work reports the first pharmacological, toxicological, and antioxidant studies of EC extract on liver injury. Liver necrosis was induced by thioacetamide (TAA). Five groups were established: Croton Extract (EC), thioacetamide (TAA), Croton extract with thioacetamide (EC + TAA), vitamin E with thioacetamide (VE + TAA) and the positive control and vehicle (CT). For EC and EC + TAA, Wistar rats (n = 8) were intragastrically pre-administered for 4 days with EC (300 mg/kg.day) and on the last day, EC + TAA received a single dose of TAA (400 mg/kg). At 24 h after damage induction, animals were sacrificed. In vitro activity and gene expression of superoxide dismutase (SOD), catalase (Cat), and Nrf2 nuclear factor were measured. The results show that EC has medium antioxidant properties, with an IC50 of 0.63 mg/mL and a ferric-reducing power of 279.8 µM/mg.Additionally, EC reduced hepatic damage markers at 24 h after TAA intoxication; also, it increased SOD and Cat gene expression against TAA by controlling antioxidant defense levels. Our findings demonstrated the hepatoprotective effect of EC by reducing hepatic damage markers and controlling antioxidant defense levels. Further studies are necessary to identify the mechanism of this protection.
PB MDPI
SN 1420-3049
YR 2019
FD 2019-07-11
LK https://hdl.handle.net/20.500.14352/12722
UL https://hdl.handle.net/20.500.14352/12722
LA eng
NO CONACYT, Mexico
DS Docta Complutense
RD 9 abr 2025