RT Journal Article
T1 Antioxidant Mechanisms and ROS-Related MicroRNAs in Cancer Stem Cells
A1 Dando, Ilaria
A1 Cordani, Marco
A1 Dalla Pozza, Elisa
A1 Biondani, Giulia
A1 Donadelli, Massimo
A1 Palmieri, Marta
AB Increasing evidence indicates that most of the tumors are sustained by a distinct population of cancer stem cells (CSCs), which are responsible for growth, metastasis, invasion, and recurrence. CSCs are typically characterized by self-renewal, the key biological process allowing continuous tumor proliferation, as well as by differentiation potential, which leads to the formation of the bulk of the tumor mass. CSCs have several advantages over the differentiated cancer cell populations, including the resistance to radio- and chemotherapy, and their gene-expression programs have been shown to correlate with poor clinical outcome, further supporting the relevance of stemness properties in cancer. The observation that CSCs possess enhanced mechanisms of protection from reactive oxygen species (ROS) induced stress and a different metabolism from the differentiated part of the tumor has paved the way to develop drugs targeting CSC specific signaling. In this review, we describe the role of ROS and of ROS-related microRNAs in the establishment and maintenance of self-renewal and differentiation capacities of CSCs.
PB Hindawi
SN 1942-0900
YR 2015
FD 2015
LK https://hdl.handle.net/20.500.14352/97265
UL https://hdl.handle.net/20.500.14352/97265
LA eng
NO Dando, Ilaria, et al. «Antioxidant Mechanisms and ROS-Related MicroRNAs in Cancer Stem Cells». Oxidative Medicine and Cellular Longevity, vol. 2015, 2015, pp. 1-13. https://doi.org/10.1155/2015/425708.
NO Italian Association for Cancer Research
NO CariPaRo Foundation
NO Ministry of Education, University and Research (Italy)
DS Docta Complutense
RD 10 abr 2025