TY  - GEN
AU  - Nieto Sanchez, A.
AU  - Roda Navarro, Pedro
AU  - Rodríguez Perales, Sandra
PY  - 2025
DO  - 10.1186/s12943-025-02542-0
SN  - 1476-4598
UR  - https://hdl.handle.net/20.500.14352/133954
T2  - Molecular Cancer
AB  - Oncogene amplifications fuel some of the most lethal, therapy‑refractory cancers, yet remain clinically untargeted. We report a single‑guide CRISPR/Cas9 strategy that converts the sheer copy‑number excess of oncogene amplicons into an Achilles' heel....
LA  - eng
PB  - Springer Nature
KW  - CRISPR system
KW  - Cancer targeted therapy
KW  - Genome editing
KW  - Immunogenic Cell Death (ICD)
KW  - Oncogene amplification
KW  - Preclinical studies
KW  - ecDNA
TI  - Selective genome editing of amplified oncogenes triggers immunogenic cell death and tumor remodeling
TY  - review article
VL  - 25
ER  -