%0 Journal Article
%A Echeverría, Olatz
%A Alou Cervera, Luis
%A Sevillano Fernández, David
%A González Hidalgo, Natalia
%A Gómez-Lus Centelles, María Luisa
%A Aguilar, Lorenzo
%A Prieto Prieto, José
%T Pharmacodynamics of Simulated Total Versus Free-Drug Serum Concentrations of a Low Versus a High Protein Bound Third-Generation Oral Cephalosporin (Cefpodoxime Versus Cefditoren) Against Streptococcus pneumoniae
%D 2007
%@ 1120-009X
%U https://hdl.handle.net/20.500.14352/107167
%X Pharmacodynamic parameters and bactericidal activity against Streptococcus pneumoniae were investigated by simulating total and free serum concentrations of cefpodoxime versus cefditoren. Total drug T>MIC against the penicillin-intermediate (PISP) and resistant (PRSP) strains were 70.6% and 42.9% for cefpodoxime, and 89.6% and 62.5% for cefditoren, respectively. Comparing activity of free versus total cefpodoxime, there were reductions of 8.5% and 19.1% in T>MIC, related to bactericidal activity reductions from approximately 4.5 to 3 log10, and from 3 to 2.5 log10 against PISP and PRSP, respectively, at 10-12h. For cefditoren, reductions of 45.4% and 100% in T>MIC, were related to bactericidal activity reductions from approximately 5.5 to 2-2.5 log10 and from approximately 2.5 to 1.5 log10 against PISP and PRSP, respectively, at 10-12h. Higher differences in activity were found against the less resistant strains when comparing total versus free-drug profile.
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