RT Journal Article
T1 Pharmacodynamics of Simulated Total Versus Free-Drug Serum Concentrations of a Low Versus a High Protein Bound Third-Generation Oral Cephalosporin (Cefpodoxime Versus Cefditoren) Against Streptococcus pneumoniae
A1 Echeverría, Olatz
A1 Alou Cervera, Luis
A1 Sevillano Fernández, David
A1 González Hidalgo, Natalia
A1 Gómez-Lus Centelles, María Luisa
A1 Aguilar, Lorenzo
A1 Prieto Prieto, José
AB Pharmacodynamic parameters and bactericidal activity against Streptococcus pneumoniae were investigated by simulating total and free serum concentrations of cefpodoxime versus cefditoren. Total drug T>MIC against the penicillin-intermediate (PISP) and resistant (PRSP) strains were 70.6% and 42.9% for cefpodoxime, and 89.6% and 62.5% for cefditoren, respectively. Comparing activity of free versus total cefpodoxime, there were reductions of 8.5% and 19.1% in T>MIC, related to bactericidal activity reductions from approximately 4.5 to 3 log10, and from 3 to 2.5 log10 against PISP and PRSP, respectively, at 10-12h. For cefditoren, reductions of 45.4% and 100% in T>MIC, were related to bactericidal activity reductions from approximately 5.5 to 2-2.5 log10 and from approximately 2.5 to 1.5 log10 against PISP and PRSP, respectively, at 10-12h. Higher differences in activity were found against the less resistant strains when comparing total versus free-drug profile.
PB Taylor & Francis
SN 1120-009X
YR 2007
FD 2007-06
LK https://hdl.handle.net/20.500.14352/107167
UL https://hdl.handle.net/20.500.14352/107167
LA eng
NO Echeverria O, Alou L, Sevillano D, Gonzalez N, Gomez-Lus ML, Aguilar L, Prieto J. Pharmacodynamics of simulated total versus free-drug serum concentrations of a low versus a high protein bound third-generation oral cephalosporin (Cefpodoxime versus cefditoren) against Streptococcus pneumoniae. J Chemother. 2007 Jun;19(3):288-94.
NO Sankyo Pharma GmbH
DS Docta Complutense
RD 6 abr 2025