%0 Journal Article
%A Garrido Novelle, Marta
%A Naranjo Martínez, Beatriz
%A López Cánovas, Juan Luis
%A Díaz Ruíz, Alberto
%T Fecal microbiota transplantation, a tool to transfer healthy longevity
%D 2025
%@ 1568-1637
%U https://hdl.handle.net/20.500.14352/112472
%X The complex gut microbiome influences host aging and plays an important role in the manifestation of age-related diseases. Restoring a healthy gut microbiome via Fecal Microbiota Transplantation (FMT) is receiving extensive consideration to therapeutically transfer healthy longevity. Herein, we comprehensively review the benefits of gut microbial rejuvenation - via FMT - to promote healthy aging, with few studies documenting life length properties. This review explores how preconditioning donors via standard - lifestyle and pharmacological - antiaging interventions reshape gut microbiome, with the resulting benefits being also FMT-transferable. Finally, we expose the current clinical uses of FMT in the context of aging therapy and address FMT challenges - regulatory landscape, protocol standardization, and health risks - that require refinement to effectively utilize microbiome interventions in the elderly.
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