RT Journal Article
T1 Fecal microbiota transplantation, a tool to transfer healthy longevity
A1 Garrido Novelle, Marta
A1 Naranjo Martínez, Beatriz
A1 López Cánovas, Juan Luis
A1 Díaz Ruíz, Alberto
AB The complex gut microbiome influences host aging and plays an important role in the manifestation of age-related diseases. Restoring a healthy gut microbiome via Fecal Microbiota Transplantation (FMT) is receiving extensive consideration to therapeutically transfer healthy longevity. Herein, we comprehensively review the benefits of gut microbial rejuvenation - via FMT - to promote healthy aging, with few studies documenting life length properties. This review explores how preconditioning donors via standard - lifestyle and pharmacological - antiaging interventions reshape gut microbiome, with the resulting benefits being also FMT-transferable. Finally, we expose the current clinical uses of FMT in the context of aging therapy and address FMT challenges - regulatory landscape, protocol standardization, and health risks - that require refinement to effectively utilize microbiome interventions in the elderly.
PB Elsevier
SN 1568-1637
YR 2025
FD 2025-01
LK https://hdl.handle.net/20.500.14352/112472
UL https://hdl.handle.net/20.500.14352/112472
LA eng
NO Novelle, M. G., Naranjo-Martínez, B., López-Cánovas, J. L., & Díaz-Ruiz, A. (2025). Fecal microbiota transplantation, a tool to transfer healthy longevity. Ageing Research Reviews, 103, 102585. https://doi.org/10.1016/j.arr.2024.102585
NO This work was supported by the following grants: i) RETOS Projects Program PID2019-106893RA-I00 (grant to A.D.R), funded by MICIU/AEI/10.13039/501100011033; ii) Ramon y Cajal Award RYC2021-033751-I (grant to A.D.R), funded by MICIU/AEI/10.13039/501100011033 and European Union NextGenerationEU/PRTR; iii) CIVP21A7025 (grant to A.D.R), funded by Ramón Areces Foundation; iv) Talento Grant (2018-T1/BMD-11966; grant to A.D.R), funded by Comunidad de Madrid; and v) CIBERobn, an initiative of the Instituto de Salud Carlos III (ISCIII) of Spain, which is supported by FEDER funds. Figure 1 was designed by Freepik. Some Icons on Figures 2-4 were modified from BioRender.com.
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Unión Europea
NO Fundación Ramón Areces
NO Comunidad de Madrid
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 21 abr 2025