RT Journal Article
T1 Oral cortisol and dexamethasone intake: Differential physiology and transcriptional responses in the marine juvenile Sparus aurata
A1 Barany Ruiz, André
A1 Fuentes, Juan
A1 Valderrama, Víctor
A1 Broz-Ruiz, Álvaro
A1 Martínez-Rodríguez, Gonzalo
A1 Mancera, Juan Miguel
AB This study approached the long-term oral administration of cortisol (F) and dexamethasone (DEX), two synthetic glucocorticoids, compared to a control group (CT) in the juveniles of a marine teleost, the gilthead seabream (Sparus aurata). Physiologically, DEX treatment impaired growth, which appears to be linked to carbohydrate allocation in muscle and liver, hepatic triglycerides depletion, and reduced hematocrit. Hypophyseal gh mRNA expression was 2-fold higher in DEX than in CT or F groups. Similarly, hypothalamic trh and hypophyseal pomcb followed this pattern. Plasma cortisol levels were significantly lower in DEX than in CT, while F presented intermediate levels. In the posterior intestine, measured short circuit-current (Isc) was more anion absorptive in CT and F compared to the DEX group, whereas Isc remained unaffected in the anterior intestine. The derived transepithelial electric resistance (TEER) significantly differed between intestinal regions in the DEX group. These results provide new insights to understand better potential targeted biomarkers indicative of the differential glucocorticoid or mineralocorticoid-receptors activation in fish.
PB Elsevier
SN 0016-6480
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/97934
UL https://hdl.handle.net/20.500.14352/97934
LA eng
NO A. Barany, J. Fuentes, V. Valderrama, A. Broz-Ruiz, G. Martínez-Rodríguez, J.M. Mancera. Oral cortisol and dexamethasone intake: Differential physiology and transcriptional responses in the marine juvenile Sparus aurata. General and Comparative Endocrinology, Volume 344, 2023, 114371, ISSN 0016-6480, https://doi.org/10.1016/j.ygcen.2023.114371
NO Ministerio de Economía y Competitividad (España)
NO Universidad de Cádiz
DS Docta Complutense
RD 7 abr 2025