RT Journal Article
T1 The influence of meibomian gland loss on ocular surface clinical parameters
A1 Rico del Viejo, Laura
A1 Benítez del Castillo, José Manuel
A1 Gómez Sanz, Fernando Javier
A1 García Montero, María
A1 Llorens Quintana, Clara
A1 Madrid Costa, David
AB Purpose: To assess the relationship between the meibomian gland loss (MGL) and relevant ocular surface clinical parameters as well as the influence of age in this relationship.Methods: A total of 161 participants (mean age; 42±17 years) were enrolled in this study. Infrared meibography was performed using Keratograph 5M (K5M; Oculus GmbH, Wetzlar). Participants were divided into five groups according to total meiboscore and the ocular surface parameters of each MGL group were studied. In addition, the relationship between MGL and the ocular surface parameters was established including age as covariant.Results: Both eyelids were taken into account since no association between the MGL from upper and lower eyelid was found (k value=0.2; p=0.3) despite they were significantly correlated (r= 0.3; p<0.001). No statistically significant differences were found in symptomatology among different MGL groups. Statistically significant differences were found among MGL groups in tear osmolarity (p=0.02), bulbar redness (p=0.04), corneal and conjunctival staining (p=0.01 and p=0.004, respectively). Despite this, only corneal staining showed a significant correlation with MGL when age was covariant (r=0.2; p=0.04).Conclusions: MGL higher than 50% seems to be accompanied by signs on the ocular surface. Furthermore, age demonstrated to be a relevant factor when assessing MGL. For this reason, future studies should compare age-matched groups in order to know the contribution of the MGL on the ocular surface and establish valid cut-off values for dry eye diagnosis.
PB Elsevier
SN 1367-0484
YR 2019
FD 2019-04-10
LK https://hdl.handle.net/20.500.14352/13267
UL https://hdl.handle.net/20.500.14352/13267
LA eng
NO Received 19 December 2018, Revised 31 March 2019, Accepted 3 April 2019, Available online 10 April 2019.
NO Unión Europea. H2020
DS Docta Complutense
RD 29 abr 2024