RT Journal Article
T1 Creutzfeldt-Jakob Disease and Fatal Familial Insomnia: Demographics and In-Hospital Mortality in Spain
A1 Cuadrado Corrales, María Natividad
A1 López De Andrés, Ana Isabel
A1 Hernández Barrera, Valentín
A1 Miguel Díez, Javier De
A1 Jiménez Sierra, Ana
A1 Carabantes Alarcón, David
A1 Zamorano León, José Javier
A1 Jiménez García, Rodrigo
AB Background: Creutzfeldt-Jakob disease (CJD) and fatal familial insomnia (FFI) are prion diseases characterized by severe neurodegenerative conditions and a short duration of illness. Methods: This study explores the characteristics of hospitalizations for CJD and FFI in Spain from 2016 to 2022 using the Spanish National Hospital Discharge Database (SNHDD). Results: We identified a total of 1063 hospital discharges, including 1020 for CJD and 43 for FFI. Notably, the number of hospitalized patients with FFI showed a significant peak in 2017. The average length of hospital stay (LOHS) was 13 days for CJD and 6 days for FFI, with in-hospital mortality rates (IHM) of 36.37% for CJD and 32.56% for FFI. Among CJD patients, the average LOHS was 14 days, with a significantly longer duration for those who experienced IHM. Conclusions: The presence of sepsis or pneumonia and older age were associated with a higher IHM rate among CJD patients. The total estimated cost for managing CJD and FFI patients over the study period was EUR 6,346,868. This study offers new insights into the epidemiology and healthcare resource utilization of CJD and FFI patients, which may inform future research directions and public health strategies.
PB MPDI
YR 2024
FD 2024-07-27
LK https://hdl.handle.net/20.500.14352/117915
UL https://hdl.handle.net/20.500.14352/117915
LA eng
NO Cuadrado-Corrales N, Lopez-de-Andres A, Hernández-Barrera V, De-Miguel-Díez J, Jimenez-Sierra A, Carabantes-Alarcon D, Zamorano-Leon JJ, Jimenez-Garcia R. Creutzfeldt-Jakob Disease and Fatal Familial Insomnia: Demographics and In-Hospital Mortality in Spain. J Clin Med. 2024 Jul 27;13(15):4401
NO Comunidad Autónoma de Madrid
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 18 abr 2025