RT Journal Article
T1 Classification of COVID19 Patients Using Robust Logistic Regression
A1 Ghosh, Abhik
A1 Jaenada Malagón, María
A1 Pardo Llorente, Leandro
AB Coronavirus disease 2019 (COVID19) has triggered a global pandemic affecting millions of people. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the COVID-19 disease is hypothesized to gain entry into humans via the airway epithelium, where it initiates a host response. The expression levels of genes at the upper airway that interact with the SARS-CoV-2 could be a telltale sign of virus infection. However, gene expression data have been flagged as suspicious of containing different contamination errors via techniques for extracting such information, and clinical diagnosis may contain labelling errors due to the specificity and sensitivity of diagnostic tests. We propose to fit the regularized logistic regression model as a classifier for COVID-19 diagnosis, which simultaneously identifies genes related to the disease and predicts the COVID-19 cases based on the expression values of the selected genes. We apply a robust estimating methods based on the density power divergence to obtain stable results ignoring the effects of contamination or labelling errors in the data and compare its performance with respect to the classical maximum likelihood estimator with different penalties, including the LASSO and the general adaptive LASSO penalties.
PB Springer Nature
SN 1559-8608
YR 2022
FD 2022-09-21
LK https://hdl.handle.net/20.500.14352/72041
UL https://hdl.handle.net/20.500.14352/72041
LA eng
NO CRUE-CSIC (Acuerdos Transformativos 2022)
NO Ministerio de Ciencia e Innovación (MICINN)
NO Ministerio de Universidades
NO Department of Science and Technology (DST), Government of India
DS Docta Complutense
RD 9 abr 2025