TY - JOUR AU - Sánchez-Ortega, Miriam AU - Garrido, Antonio AU - Sanz, Lorena AU - Torres-Pérez, Rafael AU - Hernandez, Carmen AU - Tsao, Ming Sound AU - Carrera, Ana Clara AU - Gutiérrez Uzquiza, Álvaro PY - 2025 DO - 10.1186/s12943-025-02401-y UR - https://hdl.handle.net/20.500.14352/133157 T2 - Molecular Cancer AB - Lung squamous cell cancer (LUSC) is associated with very poor survival due to the lack of specific treatments. A common genetic alteration in LUSC involves mutations in (protein named NRF2) or its regulator, , resulting in increased activity of the... LA - eng M2 - 197 PB - Springer KW - CRISPRa/dCas9 KW - LUSC treatment; NRF2 KW - PI3Kα KW - TRIM24 TI - Double vulnerability of active-NRF2 lung squamous cell carcinoma to NRF2 and TRIM24 TY - journal article VL - 24 ER -