RT Book, Section
T1 Retinal Disorders in Humans and Experimental ALS Models
A1 Rojas Lozano, Pilar
A1 Ramírez Sebastián, Ana Isabel
A1 Hoz Montañana, María Rosa de
A1 Cadena Santoyo, Manuel
A1 García Martín, Elena Salobrar
A1 López Cuenca, Inés
A1 Fernández Albarral, José Antonio
A1 Sánchez Puebla, Lídia
A1 Matamoros, José A.
A1 Salazar Corral, Juan José
A1 Ramirez Sebastian, Jose Manuel
AB Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease that severely impairs the patient’s mobility, as it mainly affects the upper and lower motor neurons in the spinal cord. In addition, alterations have also been demonstrated in different parts of the central nervous system (CNS), such as the brain and brainstem. The retina is a projection to the brain and is considered as a “window” to the CNS. Moreover, it is possible to use the retina as a biomarker in several neurodegenerative diseases, even in the absence of major visual impairment. Classically, it was thought that the eyes were not affected in ALS, with respect to extraocular muscles, whereas the remainder of the muscles of the body were distressed. Nevertheless, retinal changes have recently been found in this pathology and could help in diagnosis, follow-up, and even monitoring therapies in this disease.
PB IntechOpen
YR 2022
FD 2022-12-13
LK https://hdl.handle.net/20.500.14352/2499
UL https://hdl.handle.net/20.500.14352/2499
LA eng
NO Submitted: July 25th, 2022 Reviewed: August 10th, 2022 Published: December 13th, 2022
DS Docta Complutense
RD 17 ago 2024