RT Journal Article
T1 An enzyme-controlled mesoporous nanomachine for triple-responsive delivery
A1 Mayol Hornero, Beatriz
A1 Dato, Victor
A1 Rodriguez, Manuel
A1 Lucena, Elena
A1 Villalonga, Anabel
A1 Díez, Paula
A1 Jiménez Falcao, Sandra
A1 Sancenón, Félix
A1 Sánchez Sánchez, Alfredo
A1 Vilela García, Diana
A1 Martínez Ruiz, María Paloma
A1 Martínez-Máñez, Ramón
A1 Villalonga Santana, Reynaldo
AB The construction of a novel enzyme-controlled nanomachine with multiple release mechanisms for oncommand delivery is described. This nanodevice was assembled by modifying mesoporous silica nanoparticles with 2-(benzo[d]thiazol-2-yl)phenyl 4-aminobenzoate moieties, and further capped with b-cyclodextrin-modified glucose oxidase neoglycoenzyme. The device released the encapsulated payload in the presence of H2O2 and acidic media. The use of glucose as an input chemical signal also triggered cargo release through the enzymatic production of gluconic acid and hydrogen peroxide, and the subsequent disruption of the gating mechanism at the mesoporous surface. The nanodevice was successfully employed for the enzyme-controlled release of doxorubicin in HeLa cancer cells.
PB The Royal Society of Chemistry
SN 2050-7518
YR 2022
FD 2022
LK https://hdl.handle.net/20.500.14352/95992
UL https://hdl.handle.net/20.500.14352/95992
LA eng
NO Mayol, B., Dato, V., Rodriguez, M., Lucena, E., Villalonga, A., Díez, P., Jimenez-Falcao, S., Sancenón, F., Sánchez, A., Vilela, D., Martínez-Ruíz, P., Martinez-Mañez, R., Villalonga, R. (2022). An enzyme-controlled mesoporous nanomachine for triple-responsive delivery. Journal of Materials Chemistry B, 10: 6983-6990
NO Financial support from the Spanish Ministry of Economy and Competitiveness (projects CTQ2017-87954-P, PID2021-125723NBI00, MAT2015-64139-C4-1 and RTI2018-100910-B-C41) is gratefully acknowledged. The authors also thank the Generalitat Valencia (Project PROMETEO/2018/024) for support.
NO Ministerio de Economia y Competitividad (España)
NO Generalitat Valenciana
DS Docta Complutense
RD 8 abr 2025