RT Journal Article
T1 Heat-inactivated mycobacteria activate the toll-like receptor 2 and 4 pathways in the zebrafish model of tuberculosis
A1 Ferreras-Colino, Elisa
A1 Contreras, Marinela
A1 Risalde, María A.
A1 Sevilla, Iker A.
A1 Delgado, Encarnación
A1 Domínguez Rodríguez, Lucas José
A1 Gortazar, Christian
A1 De la Fuente, José
AB Based on previous evidence demonstrating the efficacy of inactivated mycobacteria for the control of fish mycobacteriosis, we explored the protective efficacy of two inactivated Mycobacterium bovis administered via parenteral and mucosal routes against Mycobacterium marinum infection mimicking natural conditions in the zebrafish model of tuberculosis. Although we did not observe a clear effect of any of the immunostimulants on mycobacterial burden, the results showed a significant increase in TLR2 and TLR4 gene expression levels in fishes parenterally immunized with inactivated Bacillus Calmette-Guérin (BCG). Our findings demonstrated that the TLR2 and the TLR4 signaling pathways are involved in the immune response elicited by inactivated mycobacteria in the zebrafish model of tuberculosis and support the use of inactivated mycobacteria in vaccine formulations for the control of mycobacteriosis.
PB Elsevier
SN 0264-410X
YR 2024
FD 2024-01
LK https://hdl.handle.net/20.500.14352/102518
UL https://hdl.handle.net/20.500.14352/102518
LA eng
NO Ferreras E*, Contreras M, Risalde MA, Sevilla IA, Delgado E, Dominguez L, Gortazar C and de la Fuente J. Heat-inactivated mycobacteria activate the toll-like receptor 2 and 4 pathways in the zebrafish model of tuberculosis. Vaccine, S0264-410X(23)01544-X. 2024. (A). ISSN: 0264-410X. Impact factor 2022: 5.500. Category: Immunology, Quartile: 1, Position: 57 of 161. DOI: 10.1016/j.vaccine.2023.12.085
NO Junta de Castilla-La Mancha
NO European Social Fund
NO Ministerio de Ciencia, Innovacion ´ y Universidades
DS Docta Complutense
RD 11 abr 2025