RT Journal Article
T1 Multimodal assessment of non-alcoholic fatty liver disease with transmission-reflection optoacoustic ultrasound
A1 Lafci, Berkan
A1 Hadjihambi, Anna
A1 Determann, Madita
A1 Konstantinou, Christos
A1 Freijo, Clara
A1 López Herraiz, Joaquín
A1 Blümel, Sena
A1 Pellerin, Luc
A1 Burton, Neal C.
A1 Deán-Ben, Xosé Luís
A1 Razansky, Daniel
AB Non-alcoholic fatty liver disease (NAFLD) is an umbrella term referring to a group of conditions associated to fat deposition and damage of liver tissue. Early detection of fat accumulation is essential to avoid progression of NAFLD to serious pathological stages such as liver cirrhosis and hepatocellular carcinoma. Methods: We exploited the unique capabilities of transmission-reflection optoacoustic ultrasound (TROPUS), which combines the advantages of optical and acoustic contrasts, for an early-stage multi-parametric assessment of NAFLD in mice. Results: The multispectral optoacoustic imaging allowed for spectroscopic differentiation of lipid content, as well as the bio-distributions of oxygenated and deoxygenated hemoglobin in liver tissues in vivo. The pulse-echo (reflection) ultrasound (US) imaging further provided a valuable anatomical reference whilst transmission US facilitated the mapping of speed of sound changes in lipid-rich regions, which was consistent with the presence of macrovesicular hepatic steatosis in the NAFLD livers examined with ex vivo histological staining. Conclusion: The proposed multimodal approach facilitates quantification of liver abnormalities at early stages using a variety of optical and acoustic contrasts, laying the ground for translating the TROPUS approach toward diagnosis and monitoring NAFLD in patients.
PB Ivyspring International Publisher
SN 1838-7640
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/136789
UL https://hdl.handle.net/20.500.14352/136789
LA eng
NO Lafci, Berkan, et al. «Multimodal Assessment of Non-Alcoholic Fatty Liver Disease with Transmission-Reflection Optoacoustic Ultrasound». Theranostics, vol. 13, n.o 12, 2023, pp. 4217-28. DOI.org (Crossref), https://doi.org/10.7150/thno.78548.
NO The Swiss Data Science Center
NO European Commission
DS Docta Complutense
RD 8 jun 2026