RT Journal Article
T1 Optic nerve and macular optical coherence tomography in recovered COVID-19 patients
A1 Burgos Blasco, Bárbara
A1 Güemes Villahoz, Noemi
A1 Vidal Villegas, Beatriz
A1 Martínez De La Casa Fernández-Borrella, José María
A1 Donate López, Juan
A1 Martín Sánchez, Francisco Javier
A1 González Armengol, Juan Jorge
A1 Porta Etessam, Mariano Jesús
A1 Rodríguez Martin, José Luis
A1 García Feijoo, Julián
AB Purpose: To investigate the peripapillary retinal nerve fiber layer thickness (RNFLT), macular RNFLT, ganglion cell layer (GCL), and inner plexiform layer (IPL) thickness in recovered COVID-19 patients compared to controls.Methods: Patients previously diagnosed with COVID-19 were included, while healthy patients formed the historic control group. All patients underwent an ophthalmological examination, including macular and optic nerve optical coherence tomography. In the case group, socio-demographic data, medical history, and neurological symptoms were collected.Results: One hundred sixty patients were included; 90 recovered COVID-19 patients and 70 controls. COVID-19 patients presented increases in global RNFLT (mean difference 4.3; CI95% 0.8 to 7.7), nasal superior (mean difference 6.9; CI95% 0.4 to 13.4), and nasal inferior (mean difference 10.2; CI95% 2.4 to 18.1) sectors of peripapillary RNFLT. Macular RNFL showed decreases in COVID-19 patients in volume (mean difference −0.05; CI95% −0.08 to −0.02), superior inner (mean difference −1.4; CI95% −2.5 to −0.4), nasal inner (mean difference −1.1; CI95% −1.8 to −0.3), and nasal outer (mean difference −4.7; CI95% −7.0 to −2.4) quadrants. COVID-19 patients presented increased GCL thickness in volume (mean difference 0.04; CI95% 0.01 to 0.07), superior outer (mean difference 2.1; CI95% 0.8 to 3.3), nasal outer (mean difference 2.5; CI95% 1.1 to 4.0), and inferior outer (mean difference1.2; CI95% 0.1 to 2.4) quadrants. COVID-19 patients with anosmia and ageusia presented an increase in peripapillary RNFLT and macular GCL compared to patients without these symptoms.Conclusions: SARS-CoV-2 may affect the optic nerve and cause changes in the retinal layers once the infection has resolved.
PB SAGE Publications
SN 1120-6721
YR 2021
FD 2021-03-15
LK https://hdl.handle.net/20.500.14352/8021
UL https://hdl.handle.net/20.500.14352/8021
LA eng
NO Burgos Blasco, B., Güemes Villahoz, N, Vidal Vilegas, B. et al. «Optic Nerve and Macular Optical Coherence Tomography in Recovered COVID-19 Patients». European Journal of Ophthalmology, vol. 32, n.o 1, enero de 2022, pp. 628-36. DOI.org (Crossref), https://doi.org/10.1177/11206721211001019.
DS Docta Complutense
RD 4 abr 2025