RT Journal Article
T1 A novel Janus nanomachine based on mesoporous silica nanoparticles anisotropically modified with PAMAM dendrimers for enzyme-controlled drug delivery
A1 Mayol Hornero, Beatriz
A1 García-Díez, Esther
A1 Hoppe, Alexander
A1 Espejo, Lucía
A1 Muñoz, Miranda
A1 González Barrios, Marta María
A1 Villalonga, Anabel
A1 Moreno, Teresa
A1 Sánchez, Alfredo
A1 Vilela García, Diana
A1 Martínez Quiles, Narcisa
A1 Martínez Ruiz, María Paloma
A1 Villalonga Santana, Reynaldo
AB A masking/toposelective modification approach was employed to prepare a new organic–inorganic Janus nanomaterial by attaching ethylenediamine core polyamidoamine G-4.5 dendrimers to a defined face of mesoporous silica nanoparticles. The anisotropic colloid was then sequentially functionalized on the mesoporous face with (3-isocyanatopropyl)triethoxysilane, 1-(4-aminophenyl)-2-phenylethane-1,2- dione and β-cyclodextrin to assemble a novel H2O2-sensitive gating mechanism. The Janus nanomachine was finally constructed by immobilizing glucose oxidase on the dendrimeric face. The smart nanodevice released the encapsulated payload in the presence of H2O2 and glucose, and was successfully evaluated for the enzyme-controlled delivery of the antitumoral drug doxorubicin into HeLa cancer cells.
PB RSC
YR 2025
FD 2025
LK https://hdl.handle.net/20.500.14352/123997
UL https://hdl.handle.net/20.500.14352/123997
LA eng
NO Nanoscale, 2025, 17, 8183–8191
DS Docta Complutense
RD 30 dic 2025