RT Journal Article
T1 Short-term esmolol attenuates remodeling of the thoracic aorta in hypertensive rats by decreasing concentrations of ADMA down- regulated by oxidative stress
A1 Quintana Villamandos, María Begoña
A1 González, Maria Carmen
A1 Delgado Martos, María Jesús
A1 Condezo Hoyos, Luis
A1 Böger, Rainer
A1 Lüneburg, Nicole
A1 Pazó Sayós, Laia
A1 Gutiérrez Arzapalo, Perla Yareli
A1 Delgado Baeza, Emilio
AB Esmolol produces early regression of left ventricular hypertrophy and improves coronary artery remodeling, although the impact of short-term treatment with this beta-blocker on remodeling in large arteries has not yet been studied. We hypothesized that even a short (48h) course of esmolol might alter remodeling of the aorta in the spontaneously hypertensive rat (SHR). Fourteen-month-old male SHRs were treated intravenously with vehicle (SHR, n=8) or esmolol (SHR-E, n=8) (300μg/kg/min). Age-matched, vehicle-treated male Wistar-Kyoto rats (WKY, n=8) served as controls. After 48h, we studied the structure, volume density of elastic fibers, and passive mechanical properties of the aorta. Determination of asymmetrical dimethylarginine concentrations and total protein carbonyls in the aorta were analyzed. Esmolol significantly attenuated abnormal aortic wall thickness, cross-sectional area, wall-to-lumen ratio, volume density of elastic fibers, and wall stiffness. The protective effect of esmolol could be related to a decrease in asymmetrical dimethylarginine levels after down-regulation by oxidative stress. These findings could play a key role in the selection of antihypertensive therapy in patients with hypertension and aortic remodeling.
PB Elsevier
SN 0014-2999
YR 2016
FD 2016-09-14
LK https://hdl.handle.net/20.500.14352/98674
UL https://hdl.handle.net/20.500.14352/98674
LA eng
NO Quintana-Villamandos B, González MC, Delgado-Martos MJ, Condezo-Hoyos L, Böger RH, Lüneburg N, Pazó-Sayós L, Gutiérrez-Arzapalo PY, Delgado-Baeza E. Short-term esmolol attenuates remodeling of the thoracic aorta in hypertensive rats by decreasing concentrations of ADMA down-regulated by oxidative stress. Eur J Pharmacol. 2016 Nov 15;791:502-509. doi: 10.1016/j.ejphar.2016.09.020
NO Unión Europea
NO Ministerio de Sanidad
DS Docta Complutense
RD 24 dic 2025