RT Journal Article
T1 Bacteriological and Immunological Profiling of Meconium and Fecal Samples from Preterm Infants: A Two-Year Follow-Up Study
A1 Gómez, Marta
A1 Moles, Laura
A1 Espinosa-Martos, Irene
A1 Bustos, Gerardo
A1 de Vos, Willem
A1 Fernández Álvarez, Leonides
A1 Rodríguez Gómez, Juan Miguel
A1 Fuentes, Susana
A1 Jiménez Quintana, Esther Antonia
AB An abnormal colonization pattern of the preterm gut may affect immune maturation and exert a long-term influence on the intestinal bacterial composition and host health. However, follow-up studies assessing the evolution of the fecal microbiota of infants that were born preterm are very scarce. In this work, the bacterial compositions of fecal samples, obtained from sixteen 2-year-old infants were evaluated using a phylogenetic microarray; subsequently, the results were compared with those obtained in a previous study from samples of meconium and feces collected from the same infants while they stayed in the neonatal intensive care unit (NICU). In parallel, the concentration of a wide range of cytokines, chemokines, growth factors and immunoglobulins were determined in meconium and fecal samples. Globally, a higher bacterial diversity and a lower interindividual variability were observed in 2-year-olds’ feces, when compared to the samples obtained during their first days of life. Hospital-associated fecal bacteria, that were dominant during the NICU stay, seemed to be replaced, two years later, by genera, which are usually predominant in the healthy adult microbiome. The immune profile of the meconium and fecal samples differed, depending on the sampling time, showing different immune maturation statuses of the gut.
PB MDPI
SN 2072-6643
YR 2017
FD 2017
LK https://hdl.handle.net/20.500.14352/19147
UL https://hdl.handle.net/20.500.14352/19147
LA eng
NO Ministerio de Ciencia e Innovación (MICINN)
NO Ministerio de Sanidad y Consumo
NO The Netherlands Organization for Scientific Research
DS Docta Complutense
RD 10 abr 2025