RT Journal Article
T1 The leukocyte activation antigen CD69 limits allergic asthma and skin contact hypersensitivity
A1 Martín, Pilar
A1 Gómez, Manuel
A1 Lamana Domínguez, Amalia
A1 Matesanz Marín, Adela
A1 Cortés, José
A1 Ramírez-Huesca, Marta
A1 Barreiro, Olga
A1 López-Romero, Pedro
A1 Gutiérrez-Vázquez, Cristina
A1 Fuente, Hortensia de la
A1 Cruz Adalia, Aranzazu
A1 Sánchez-Madrid, Francisco
AB Background:Allergic diseases have a major health care impact in industrialized countries. The development of these diseases is influenced by exposure to allergen and to immunological and genetic factors. However, the molecular mechanisms underlying the inflammatory response that triggers allergy are not well defined.Objective:We have investigated the role of the leukocyte activation antigen CD69 in the regulation of two allergic diseases, asthma and contact dermatitis.Methods:Analysis of two models of allergic diseases in CD69 knockout and wild-type mice: ovalbumin-induced allergic airway inflammation (BALB/c genetic background) and contact hypersensitivity to oxazolone (C57BL/6J genetic background).Results:CD69 deficiency dramatically enhanced the inflammatory response in the ovalbumin-induced asthma model of antigen-induced airway allergy. CD69 knockout mice showed exacerbated pulmonary eosinophil recruitment, high vascular cell adhesion molecule 1 expression levels in lung vasculature, and enhanced TH2 and TH17 cytokines in the bronchoalveolar space and lung tissue. In the hapten-induced cutaneous contact hypersensitivity model, both CD69 deficiency and treatment with anti-CD69 mAb increased inflammation. Treatment with contact allergens induced enhanced TH1 and TH17 responses in CD69 deficient mice, and neutralizing anti–IL-17 antibodies reduced skin inflammation. In both experimental systems, adoptive transfer of lymph node cells from CD69 knockout mice increased the inflammatory response in recipient mice.
PB Elsevier
SN 0091-6749
YR 2010
FD 2010
LK https://hdl.handle.net/20.500.14352/94019
UL https://hdl.handle.net/20.500.14352/94019
LA eng
NO Martín, Pilar, et al. «The Leukocyte Activation Antigen CD69 Limits Allergic Asthma and Skin Contact Hypersensitivity». Journal of Allergy and Clinical Immunology, vol. 126, n.o 2, agosto de 2010, pp. 355-365.e3. https://doi.org/10.1016/j.jaci.2010.05.010.
NO Ministerio de Ciencia e Innovación (España)
NO Comunidad de Madrid
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 10 abr 2025