RT Journal Article
T1 Carbapenemase-Producing Elizabethkingia Meningoseptica from Healthy Pigs Associated with Colistin Use in Spain
A1 Miguela Villoldo, Pedro
A1 Hernández, Marta
A1 Moreno Romo, Miguel Ángel
A1 Rodríguez-Lázaro, David
A1 Quesada, Alberto
A1 Ugarte Ruiz, María
A1 Domínguez Rodríguez, Lucas José
AB Carbapenems are considered last-resort antimicrobials, especially for treating infections involving multidrug-resistant Gram-negative bacteria. In recent years, extended-spectrum β-lactamase (ESBL) and carbapenemase-producing Gram-negative bacteria have become widespread in hospitals, community settings, and the environment, reducing the range of effective therapeutic alternatives. The use of colistin to treat infection caused by these multi-drug bacteria may favour the selection and persistence of carbapenem-resistant bacteria. In this study, it is described, for the first time to our knowledge, a carbapenemase-producing isolate of Elizabethkingia meningoseptica from healthy pigs in Spain. The isolate we report was recovered during a study to detect colistin-resistant bacteria from faecal samples of healthy food-production animals using a chromogenic selective medium. Unexpectedly, we found an isolate of Elizabethkingia meningoseptica with high Minimum Inhibitory Concentration (MIC) values for several antibiotics tested. Molecular analysis did not show any mcr family genes related with colistin resistance, but two carbapenemase genes, blaB-12_1 and blaGOB-17_1, were detected. This finding in healthy animals could suggest that colistin may favour the selection and persistence of carbapenem-resistant bacteria.
PB MDPI
SN 2079-6382
YR 2019
FD 2019-09-11
LK https://hdl.handle.net/20.500.14352/12504
UL https://hdl.handle.net/20.500.14352/12504
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
NO Comunidad de Madrid
NO Ministerio de Ciencia e Innovación (MICCIN)
DS Docta Complutense
RD 14 dic 2025