RT Journal Article
T1 Electrical stimuli to increase cell proliferation on carbon nanotubes/mesoporous silica composites for drug delivery
A1 Vila Juárez, Mercedes
A1 Cicuéndez Maroto, Mónica
A1 Sánchez-Marcos, Jorge
A1 Fal-Miyar, Vanesa
A1 Manzano García, Miguel
A1 Prieto, Carlos
A1 Vallet Regí, María Dulce Nombre
A1 Prieto Martín, Carlos
AB The development of smart materials as bone implants is nowadays a challenging task to optimize their fast osteointegration. Nevertheless, no attempts have been done in joining the possibility of using electrical stimulation and drug delivery together in a material intended for bone tissue engineering. Moreover, the use of this synergy to induce bone healing is still limited until novel drug reservoirs material formulations allow an efficient applicability of the electrical stimuli. Herein, we present the biological response of osteoblasts cells, cultured over carbon nanotubes–mesoporous silica composites while exposed to external electrical stimulus. Moreover, its ability to function as drug delivery systems is also demonstrated. Bone cell metabolism was stimulated and mitochondrial activity was increased up to seven times in the presence of these composites under electrical stimulus, suggesting their potential application in bone regeneration processes
PB Wiley
YR 2013
FD 2013
LK https://hdl.handle.net/20.500.14352/96636
UL https://hdl.handle.net/20.500.14352/96636
LA eng
NO Vila M, Cicuéndez M, Sánchez-Marcos J, Fal-Miyar V, Manzano M, Prieto C, Vallet-Regi M. 2013. Electrical stimuli to increase cell proliferation on carbon nanotubes/mesoporous silica composites for drug delivery. J Biomed Mater Res Part A 2013:101A:213–221
NO Fondo Social Europeo
NO Ministerio de Ciencia e Innovación(España)
DS Docta Complutense
RD 5 abr 2025