RT Journal Article
T1 Lymphovascular Space Invasion in Early-Stage Endometrial Cancer (LySEC): Patterns of Recurrence and Predictors. A Multicentre Retrospective Cohort Study of the Spain Gynecologic Oncology Group
A1 Oliver Pérez, María De Los Reyes
A1 Padilla Iserte, Pablo
A1 Arencibia Sánchez, Octavio
A1 Martín Arriscado, Cristina
A1 Muruzabal, Juan Carlos
A1 Díaz Feijóo, Berta
A1 Cabrera, Silvia
A1 Coronado Martín, Pluvio Jesús
A1 Martín Salamanca, M. Belén
A1 Pantoja Garrido, Manuel
A1 Marcos Sanmartin, Josefa
A1 Cabezas López, Elena
A1 Lorenzo, Cristina
A1 Beric, Duska
A1 Rodríguez Hernández, José Ramón
A1 Roldán Rivas, Fernando
A1 Gilabert Estrelles, Juan
A1 Sánchez, Lourdes
A1 Laseca Modrego, María
A1 Tauste Rubio, Carmen
A1 Gil Ibáñez, Blanca
A1 Tejerizo García, Álvaro
AB The main aim is to compare oncological outcomes and patterns of recurrence of patients with early-stage endometrioid endometrial cancer according to lymphovascular space invasion (LVSI) status. The secondary objective is to determine preoperative predictors of LVSI. We performed a multicenter retrospective cohort study. A total of 3546 women diagnosed with postoperative early-stage (FIGO I-II, 2009) endometrioid endometrial cancer were included. Co-primary endpoints were disease-free survival (DFS), overall survival (OS), and pattern of recurrence. Cox proportional hazard models were used for time-to-event analysis. Univariate and multivariate logistical regression models were employed. Positive LVSI was identified in 528 patients (14.6%) and was an independent prognostic factor for DFS (HR 1.8), OS (HR 2.1) and distant recurrences (HR 2.37). Distant recurrences were more frequent in patients with positive LVSI (78.2% vs. 61.3%, p < 0.01). Deep myometrial invasion (OR 3.04), high-grade tumors (OR 2.54), cervical stroma invasion (OR 2.01), and tumor diameter ≥ 2 cm (OR 2.03) were independent predictors of LVSI. In conclusion, in these patients, LVSI is an independent risk factor for shorter DFS and OS, and distant recurrence, but not for local recurrence. Deep myometrial invasion, cervical stroma invasion, high-grade tumors, and a tumor diameter ≥ 2 cm are independent predictors of LVSI.
PB MPDI
YR 2023
FD 2023-04-26
LK https://hdl.handle.net/20.500.14352/103440
UL https://hdl.handle.net/20.500.14352/103440
LA eng
NO Oliver-Perez, M.R.; Padilla-Iserte, P.; Arencibia-Sanchez, O.; Martin-Arriscado, C.; Muruzabal, J.C.; Diaz-Feijóo, B.; Cabrera, S.; Coronado, P.; Martín-Salamanca, M.B.; Pantoja-Garrido, M.; et al. Lymphovascular Space Invasion in Early-Stage Endometrial Cancer (LySEC): Patterns of Recurrence and Predictors. A Multicentre Retrospective Cohort Study of the Spain Gynecologic Oncology Group. Cancers 2023, 15, 2612. https://doi.org/10.3390/cancers15092612
NO In patients with early-stage endometrioid endometrial cancer, the presence of lymph vascular space involvement (LVSI) correlates with nodal metastases, shorter disease-free survival and overall survival. However, the effect of LVSI on recurrence patterns of these patients has been poorly studied, and the optimal adjuvant treatment remains unclear. Additionally, positive LVSI is indicative for nodal assessment, however, this parameter is usually not Known until a final pathology report. The main aim of our study was to analyze oncological outcomes and patterns of recurrence of these patients according to LVSI status, as well as to determine preoperative predictors of positive LVSI. We confirmed in a large multi-institutional cohort of patients (3546 participants), that positive LVSI is an independent prognostic factor for distant recurrences (HR 2.37) but not for local recurrence. In addition, deep myometrial invasion, high-grade tumors, cervical stroma invasion, and tumor diameter ≥ 2 cm are independent predictors of positive LVSI.
DS Docta Complutense
RD 12 abr 2025