%0 Journal Article
%A López Cuenca, Inés
%A Hoz Montañana, María Rosa de
%A Alcántara Rey, Celia
%A García Martín, Elena Salobrar
%A Elvira Hurtado, Lorena
%A Fernández Albarral, José Antonio
%A Barabash, Ana
%A Ramírez Toraño, Federico
%A Frutos Lucas, Jaisalmer de
%A Salazar Corral, Juan José
%A Ramírez Sebastián, Ana Isabel
%A Ramirez Sebastian, Jose Manuel
%T Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer’s Disease
%D 2021
%@ 2227-9059
%U https://hdl.handle.net/20.500.14352/8353
%X A family history (FH+) of Alzheimer’s disease (AD) and ε4 allele of the ApoE gene are the main genetic risk factors for developing AD, whereas ε4 allele plays a protective role in age-related macular degeneration. Ocular vascular changes have been reported in both pathologies. We analyzed the choroidal thickness using optical coherence tomography (OCT) and the foveal avascular zone (FAZ) using OCT-angiography and compared the results with ApoE gene expression, AD FH+, and the presence or absence of hard drusen (HD) in 184 cognitively healthy subjects. Choroidal thickness was statistically significantly different in the (FH−, ε4−, HD+) group compared with (i) both the (FH−, ε4−, HD−) and the (FH+, ε4+, HD+) groups in the superior and inferior points at 1500 µm, and (ii) the (FH+, ε4−, HD+) group in the superior point at 1500 µm. There were statistically significant differences in the superficial FAZ between the (FH+, ε4−, HD+) group and (i) the (FH+, ε4−, HD−) group and (ii) the (FH+, ε4+, HD−) group. In conclusion, ocular vascular changes are not yet evident in participants with a genetic risk of developing AD.
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