RT Journal Article
T1 Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer’s Disease
A1 López Cuenca, Inés
A1 Hoz Montañana, María Rosa de
A1 Alcántara Rey, Celia
A1 García Martín, Elena Salobrar
A1 Elvira Hurtado, Lorena
A1 Fernández Albarral, José Antonio
A1 Barabash, Ana
A1 Ramírez Toraño, Federico
A1 Frutos Lucas, Jaisalmer de
A1 Salazar Corral, Juan José
A1 Ramírez Sebastián, Ana Isabel
A1 Ramirez Sebastian, Jose Manuel
AB A family history (FH+) of Alzheimer’s disease (AD) and ε4 allele of the ApoE gene are the main genetic risk factors for developing AD, whereas ε4 allele plays a protective role in age-related macular degeneration. Ocular vascular changes have been reported in both pathologies. We analyzed the choroidal thickness using optical coherence tomography (OCT) and the foveal avascular zone (FAZ) using OCT-angiography and compared the results with ApoE gene expression, AD FH+, and the presence or absence of hard drusen (HD) in 184 cognitively healthy subjects. Choroidal thickness was statistically significantly different in the (FH−, ε4−, HD+) group compared with (i) both the (FH−, ε4−, HD−) and the (FH+, ε4+, HD+) groups in the superior and inferior points at 1500 µm, and (ii) the (FH+, ε4−, HD+) group in the superior point at 1500 µm. There were statistically significant differences in the superficial FAZ between the (FH+, ε4−, HD+) group and (i) the (FH+, ε4−, HD−) group and (ii) the (FH+, ε4+, HD−) group. In conclusion, ocular vascular changes are not yet evident in participants with a genetic risk of developing AD.
PB MDPI
SN 2227-9059
YR 2021
FD 2021-06-02
LK https://hdl.handle.net/20.500.14352/8353
UL https://hdl.handle.net/20.500.14352/8353
LA eng
NO Received: 6 May 2021 / Accepted: 1 June 2021 / Published: 2 June 2021.
NO Instituto de Salud Carlos III/FEDER
NO Ministerio de Economía y Competitividad (MINECO)
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 17 ago 2024